The molecular mechanisms of post-adhesive transmigration of T cells

• Authors: J. Masuyama
• Languages of publication: EN

Abstracts

EN

Leukocyte extravasation is an essential phenomenon in inflammatory responses of the body. However, less is known about the mechanisms of transendothelial migration of leukocytes subsequent to their adhesion to the endothelium. It could be considered that at least three different cellular responses participate in the transmigration of adherent leukocytes: 1) polarization of adherent cells in cell shape, 2) interactions between adherent cells and molecules bound to the endothelial surface to stimulate migration through the junction between adjacent endothelial cells, and 3) co-ordination with endothelial cells to open the junction. Molecules involved in these events are discussed in this review.

Keywords

EN

ENDOTHELIAL CELL; T CELL; TRANSMIGRATION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 2
• Pages: 121-128

Contributors

author

J. Masuyama

• Document Type: REVIEW
• Publication order reference: J. Masuyama, Division of Rheumatology and Clinical Immunology, Jichi Medical School Minamikawachi-machi Tochigi, 329-0498, Japan