Genetic aspects of Alzheimer's disease

• Authors: C. Zekanowski , D. Religa , C. Graff , S. Filipek , J. Kuznicki
• Languages of publication: EN

Abstracts

EN

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Mutations in presenilin 1 gene (PSEN1), located on chromosome 14, more rarely in amyloid-beta protein precursor (APP) on chromosome 21, and presenilin 2 genes (PSEN2) on chromosome 1, underlie the pathogenesis of most cases of familial early onset of AD (EOAD). The genetics of late-onset AD (LOAD) have been more enigmatic and the only confirmed risk factor for LOAD remains the apolipoprotein E4 allele (ApoE4) on chromosome 19. In this review, we discuss the genetics of AD with a focus on the role of the APP and presenilins.

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2004
• Volume: 64
• Issue: 1
• Pages: 19-31

Contributors

author

C. Zekanowski

author

D. Religa

author

C. Graff

author

S. Filipek

author

J. Kuznicki

• Document Type: REVIEW
• Publication order reference: C. Zekanowski, Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, 4 Trojdena St., 02-109 Warsaw, Poland