Effect of variants in the ovine skeletal-muscle-specific calpain gene on body weight

• Authors: H. Chung , B. Choi , G. Jang , K. Lee , H. Kim , S. Yoon , S. Im , M. Davis , H. Hines
• Languages of publication: EN

Abstracts

EN

The ovine skeletal-muscle-specific calpain gene (p94), which is known also as the n-calpain or calpain 3 gene (CAPN3), was screened with primers. Selection of the PCR primers was based on the ovine cDNA sequence (GenBank accession No. AF087570). After sequence alignment between the ovine and human (AY902237) genes, exon and intron boundaries were determined. Polymorphisms were observed in the intron region for the CAPN31112 and CAPN31213 segments, and the sequences for these segments were submitted to the GenBank (AF309635 and AY102617, respectively). Body weight was recorded at birth, weaning and post-weaning. Calpain 3 genotypes of the CAPN31112 segment were associated with birth weight (P < 0.01), and a dominant gene effect was observed. Breeding group, birth type, and rearing type were significantly associated with weight traits. Allele frequencies were similar in purebred and crossbred animals.

Keywords

EN

CALPAIN 3; GROWTH; OVINE

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2007
• Volume: 48
• Issue: 3
• Pages: 63-68

Contributors

author

H. Chung

author

B. Choi

author

G. Jang

author

K. Lee

author

H. Kim

author

S. Yoon

author

S. Im

author

M. Davis

author

H. Hines

• Document Type: ARTICLE
• Publication order reference: H.Y. Chung, Animal Genomics and Bioinformatics Division, National Livestock Research Institute, Suwon 441?701 Korea