Association analysis of thyroglobulin gene variants with carcass and meat quality traits in beef cattle

• Authors: G.-F. Gan , L.-P. Zhang , J.-Y. Li , G.-Y. Hou , H.-D. Li , X. Gao , H.-Y. Ren , J.-B. Chen , S.-Z. Xu
• Languages of publication: EN

Abstracts

EN

Thyroid hormones play an important role in regulating the metabolism and can affect the homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3? flanking region of the TG gene. The SNP marker association analysis indicated that the SNP markers G133C, G156A, C220T and A506C were significantly associated with marbling score (P<0.05, N=271). Animals with the new homozygote genotype had higher marbling scores than those with the other genotypes. Besides, the linkage disequilibrium analysis indicated that these 4 SNPs were completely linked (r2 = 1). Results of this study suggest that the TG-gene-specific SNP may be a useful marker for meat quality traits in future marker-assisted selection programmes in beef cattle.

Keywords

EN

ASSOCIATION ANALYSIS; BEEF CATTLE; SNP POLYMORPHISM; THYROGLOBULIN GENE

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2008
• Volume: 49
• Issue: 3
• Pages: 251-255

Contributors

author

G.-F. Gan

author

L.-P. Zhang

author

J.-Y. Li

author

G.-Y. Hou

author

H.-D. Li

author

X. Gao

author

H.-Y. Ren

author

J.-B. Chen

author

S.-Z. Xu

• Document Type: ARTICLE
• Publication order reference: Shang-Zhong Xu, Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R. China