Rennin inhibitors containinig statine and 6-aminohexanoic acid. Part III

• Authors: Ryszard Paruszewski , Jadwiga Tautt , Jadwiga Dudkiewicz
• Languages of publication: EN

Abstracts

EN

Five peptide renin inhibitors were synthesized and their potency was assayed in vitro by a spectrofluorometric method (assay of Leu-Val-Tyr-Ser released from N-acetyltetradecapeptide substrate by renin in the presence of an inhibitor). Their stability was tested by assay of Phe and Pro-Phe released after incubation with chymotrypsin. The most potent inhibitor was Boc-Phe-His-Sta-epsilonAhx-OME, the most stable - Boc-Pro-Phe-His-Sta-epsilonAhx-OME (resistant to incubation with chymotrypsin for 4 h).

Keywords

EN

6-AMINOHEXANOIC ACID; INHIBITORY POTENCY; RENNIN INHIBITOR; STATINE

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 1
• Pages: 75-82

Contributors

author

Ryszard Paruszewski

author

Jadwiga Tautt

author

Jadwiga Dudkiewicz

• Document Type: article
• Publication order reference: Ryszard Paruszewski