Modulation of apoptosis signaling for cancer therapy

• Authors: S. Fulda , K.-M. Debatin
• Languages of publication: EN

Abstracts

EN

Apoptosis, the cell's intrinsic death program, plays a central role in regulating tissue homeostasis. Also, most cytotoxic therapies used for cancer treatment, such as chemotherapy, g-irradiation, suicide genes, or immunotherapy, predominantly act by triggering apoptosis in target cells. Thus, understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Therefore, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.

Keywords

EN

APOPTOSIS; CANCER THERAPY; RESISTANCE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2006
• Volume: 54
• Issue: 3
• Pages: 173-175

Contributors

author

S. Fulda

author

K.-M. Debatin

• Document Type: REVIEW
• Publication order reference: Simone Fulda, Ph.D., University Children?s Hospital, Eythstr. 24, D-89075 Ulm, Germany