Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus

• Authors: T. Miki , H. Kuma , T. Yokoyama , K. Sumitani , Y. Matsumoto , T. Kusaka , K. Warita , Y.-Y. Wang , N. Hosomi , T. Imagawa , K.S. Bedi , S. Itoh , Y. Nakamura , Y. Takeuchi
• Languages of publication: EN

Abstracts

EN

Effects of early postnatal ethanol exposure on brain-derived neurotrophic factor (BDNF) mRNA expression in the rat hippocampus were investigated. Wistar rats were assigned to either ethanol treatment (ET), separation control (SC) or mother-reared control (MRC) groups. Ethanol exposure was achieved by a vapor inhalation method for 3 hours a day between postnatal days (PND) 10-15. On PND 16, 20, 30, and 60, the expression of BDNF mRNA in the hippocampus was determined using real-time RT-PCR analysis. There was a significant age-related increase in the BDNF mRNA expression between PND 3060 in MRC animals. The BDNF mRNA expression in ET rats was increased at both PND 16 and 20 and thereafter decreased at PND 60 compared to SC animals. Such age-related fluctuation in the expression of BDNF mRNA differed from that of MRC animals. The exact functional implications, if any, of these ethanol-induced changes in BDNF mRNA expression remain unknown although it can be speculated that they may have an effect on the behaviors known to be influenced by the hippocampal formation.

Keywords

EN

FETAL ALCOHOL SYNDROME; HIPPOCAMPUS; NEUROTOXICITY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2008
• Volume: 68
• Issue: 4
• Pages: 484-493

Contributors

author

T. Miki

author

H. Kuma

author

T. Yokoyama

author

K. Sumitani

author

Y. Matsumoto

author

T. Kusaka

author

K. Warita

author

Y.-Y. Wang

author

N. Hosomi

author

T. Imagawa

author

K.S. Bedi

author

S. Itoh

author

Y. Nakamura

author

Y. Takeuchi

• Document Type: ARTICLE
• Publication order reference: Takanori Miki, Departments of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan