Specific inhibitors of the <plasminogen activators>

• Authors: Marek Mirowski , Ryszard Wierzbicki
• Languages of publication: PL

Abstracts

EN

The article contains a survay of the recent papers on the <fibrinolytic inhibitors> which regulate the process of <plasminogen activation> - PAI-1 and PAI-2. Both of them belong to serine <protease inhibitors> family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1 : 1 with them. PAI-1, secreted mainly by <endothelial cells> and <platelets>, is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from <placenta>, appears in <blood> during <pregnancy>.

Keywords

EN

BIOLOGICAL ACTIVITY; PATHOLOGY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1993
• Volume: 47
• Issue: 2
• Pages: 147-157

Contributors

author

Marek Mirowski

author

Ryszard Wierzbicki

• Document Type: article
• Publication order reference: Marek Mirowski