CGP 42112A abolishes facilitation of recognition caused by angiotensin II and angiotensin II(3-7) in rats

• Authors: J.J. Braszko , A. Kulakowska , M.M. Winnicka , W. Karwowska-Polecka
• Languages of publication: EN

Abstracts

EN

The role of the angiotensin AT2 receptors in some behavioural effects of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole each, substantially improved object recognition memory and enhanced apomorphine (1 mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A per se ineffective in all tests, abolished activity of both peptides. None of the treatments significantly changed behaviour of rats in open field. The results point to the considerable involvement of the AT2 angiotensin receptors in the improvement of recognition memory caused by Ang II and Ang II(3-7).

Keywords

EN

ANGIOTENSIN II; ANGIOTENSIN III; AT2 RECEPTOR; RAT; RECOGNITION MEMORY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1997
• Volume: 57
• Issue: 3
• Pages: 227-234

Contributors

author

J.J. Braszko

author

A. Kulakowska

author

M.M. Winnicka

author

W. Karwowska-Polecka

• Document Type: article
• Publication order reference: J.J.Braszko, Department of Pharmacology, Medical Academy of Bialystok, 2c Mickiewicz St., 15-222 Bialystok, Poland