Influence of bombesin on thresholds for feeding and reward in the rat

• Authors: T. Bushnik , C. Bielajew , A.M.T. Konkle , Z. Merali
• Languages of publication: EN

Abstracts

EN

Bombesin's purported role in satiety mechanisms prompted this investigation of its effects on thresholds for stimulation-induced feeding and self-stimulation in the rat. Single electrodes were implanted in the lateral hypothalamus and the ability of each electrode to support self-stimulation and stimulation-induced feeding was evaluated at four current levels between 80 and 320 muA. The frequency thresholds associated with each current value were assessed following four intraperitoneal doses of bombesin, 2, 4, 8, and 16 mug/kg, as well as a saline dose. Bombesin increased the thresholds for stimulation-induced feeding at doses known to reduce food intake without influencing self-stimulation thresholds. From these findings we conclude that (1) the effects of peripheral bombesin on stimulation-induced feeding are analogous to its effects on normal feeding and (2) the data provide additional evidence for a pharmacological dissociation between stimulation-induced feeding and reward.

Keywords

EN

BOMBESIN; GASTRIN-RELEASING PEPTIDE; SATIETY BRAIN-STIMULATION; SELF STIMULATION; STIMULATION-INDUCED FEEDING

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1999
• Volume: 59
• Issue: 4
• Pages: 295-303

Contributors

author

T. Bushnik

author

C. Bielajew

author

A.M.T. Konkle

author

Z. Merali

• Document Type: article
• Publication order reference: C. Bielajew, School of Psychology, University of Ottawa, 11 Marie Curie St., Ottawa, Ontario, Canada, K1N 6N5, Email: [e-mail].