Antilymphocyte globulin with a small dose of cyclosporine A and prednisone as the induction of immunosuppression> in renal allograft recipients

• Authors: Maria Boratynska , Tomasz Szepietowski , Zenon Szewczyk , Zygmunt Szydlowski
• Languages of publication: EN

Abstracts

EN

In attempt to avoid a detrimental synergism between CsA and renal ischemia in the immediate postoperative perion, ALG (425 limphocytotxic units/kg) with small doses of CsA (6-8 mg/kg) and P were applied as the initial immunosuppressive therapy in 14 recipients of cadaveric kidneys. ALG was administered for 5 to 14 days and 2 days before withdrawing ALG, Aza (2 mg/kg) was intorduced. Results of this protocol were compared with those of 19 pts treated with CsA (12 mg/kg) and P. All the pts were followed for at least 12 months. The duration of <posttransplant anuria> was significantly reduced in the ALG/CsA/P group (psmaller than 0.02). The sCr concentration after 12 months of observation was significantly lower(p smaller than 0.05), no alterations in urinalysis were detected. the number of <hypertensive pts> was decreased. The acute rejection rates were equivalent in both groups, however 3 of 4 rejections in ALG/CsA/P group were resistant to steroids and occurred in pts with shortened period of ALG administration. The one year patient and graft survival in the ALG/CsA/P and control groups were respecitvely: 78.5%, 71.4% and 89.4%, 78.9%. Severe infectious complications in the group treated with ALG/CsA/P occurred in pts who were subsequently treated with OKT3.

Keywords

EN

ALLOGRAFT; ANTILYMPHOCYTE; CYCLOSPORIN A; IMMUNOSUPPRESSION; PREDNISONE; RENAL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 1992
• Volume: 40
• Issue: 2
• Pages: 163-168

Contributors

author

Maria Boratynska

author

Tomasz Szepietowski

author

Zenon Szewczyk

author

Zygmunt Szydlowski

• Document Type: article