Properties of the transmission-disequilibrium test for the detection of quantitative trait loci in livestock

• Authors: J. Szydlowski , Z. Liu , V. Wilda

Abstracts

EN

The transmission-disequilibrium test (TDT) is a model-free method to detect linkage between a marker and a trait locus. Originally developed to map disease genes in human genetics, this statistic has been recently extended to deal with quantitative characters. The emphasis of current research is on investigating statistical properties of the test applied to data from livestock populations. For various constellations of sample parameters, it is shown via simulation that the empirically derived null hypothesis distribution of TDT remains in good agreement with its asymptotic distribution while its power is satisfactory only for very close linkage. TDT is then applied to a real data set from milk production data of a dairy cattle population.

Keywords

EN

DAIRY CATTLE; QUANTITATIVE TRAIT LOCI

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 1998
• Volume: 39
• Issue: 4
• Pages: 309-319

Contributors

author

J. Szydlowski

author

Z. Liu

author

V. Wilda

• Publication order reference: J. Szyda, Department of Animal Genetics, Agricultural University of Wroclaw, ul. Kozuchowska 7, 51-631 Wroclaw, Poland.