Significance of tumor cell ? receptors in human cancer

• Authors: J. Zeromski
• Languages of publication: EN

Abstracts

EN

Every tumor cell is equipped with an array of biologically active surface molecules, and several these function as receptors for various ligands. They include MHC, or in the case of humans, HLA antigens, cytokine receptors, cell-adhesion molecules, growth factor receptors, Fas/Fas-ligand molecules and others. Their expressions are a subject to alterations, usually to the advantage of tumor growth and spread. Some appear on tumor cells de novo, having no counterparts on the respective normal cells. Detailed knowledge about the expression of tumor-cell receptors and their genotypes, in particular of cancerous ones, may provide information essential for the creation of tools for specific tumor immunotherapy.

Keywords

EN

ADHESION MOLECULE; CYTOKINE RECEPTOR; GROWTH FACTOR; HLA ANTIGEN

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 2
• Pages: 105-110

Contributors

author

J. Zeromski

• Document Type: REVIEW
• Publication order reference: J. Zeromski, Chair and Department of Clinical Immunology, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland