HIV-macrophage interactions at the cellular and molecular level

• Authors: M. Khat , W. James , S. Gordon
• Languages of publication: EN

Abstracts

EN

Macrophages, centrally involved in both the innate and adaptive arms of the immune system, are not only the chief target of the human immunodeficiency virus (HIV), but also its main reservoir and vehicle of transmission. Macrophage-tropic viruses are responsible for the initial infection, predominate in the asymptomatic phase, and persist throughout infection, even after the emergence of preferential T cell- and/or dual-tropic HIV-1 variants. Functional impairment of HIV-infected macrophages plays a role in the immune dysregulation characteristic of AIDS (acquired immunodeficiency syndrome). Efforts directed ant understanding the cellular and molecular mechanisms underlying HIV-macrophage interactions remain the basis for devising novel and efficacious therapeutic strategies against HIV and the AIDS epidemic

Keywords

EN

AIDS; HIV; MACROPHAGE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 5
• Pages: 367-378

Contributors

author

M. Khat

author

W. James

author

S. Gordon

• Document Type: REVIEW
• Publication order reference: M.Khati, Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom