Evolution of eukaryotic chromosomes ? from databases to computer modeling

• Authors: D. Mackiewicz , W. Waga , S. Cebrat
• Languages of publication: EN

Abstracts

EN

Computer simulations of chromosomes' and genomes' evolution suggest that the genes located on relatively large and densely packed chromosomes should be grouped in clusters. Clusters located on homologous chromosomes may complement their defects or they may co-operate providing selective advantage to their hosts. Since recombination inside clusters is harmful, selection leads to the uneven distribution of recombination events along chromosomes - relatively high recombination in the subtelomeric regions and low recombination in the central regions of chromosomes. Uneven distribution of recombinations enables sympatric speciation which can not be predicted by the mean field theories of evolution. Further studies of chromosome evolution require more precise data (the best ? full sequences) of many closely related genomes belonging to the same species.

Keywords

EN

CHROMOSOME; GENOME EVOLUTION; MONTE CARLO SIMULATION; RECOMBINATION

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2010
• Issue: 4
• Pages: 131-145

Contributors

author

D. Mackiewicz

author

W. Waga

author

S. Cebrat

• Document Type: REVIEW
• Publication order reference: Stanislaw Cebrat, Zaklad Genomiki, Wydzial Biotechnologii, Uniwersytet Wroclawski, ul. Przybyszewskiego 63/77, Wroclaw, Poland