Frequency of micronuclei in mouse peropheral erythrocytes following WR -2721 application and X-irradiation

• Authors: L. Mazur
• Languages of publication: EN

Abstracts

EN

The grequency of micronucleated polychromatic erythrocytes (MNPCEs) in the mouse peripheral bloos was assessed after WR-2721 (S-2-/3-aminopropylamino/ethylphosphorothioic acid) application and X-irradiation.The genotoxic was demonstratred for X-rays and WR-2721, as well as a protective effect of the thiol drug against X-ray-induced genotoxicity in the erythropoietic system.After X-irradiation of the mice, the number of MNPCEs was distincly increased.WR-2721 administration prior to X-irradiation resulted in a reduction of the X-ray- induced rise in the frequency of micronuclei.WR-2721 given alone, without subsequent X-irradiation, increased the number of MNPCES.The genotoxic and radioprotective effect of WR-2721 depended on the dose applied and the time interval between the thiol agent treatment and exposure of the mice to X-rays.

Keywords

EN

IN VIVO MICRONUCLEUS ASSAY; MOUSE; X-RAY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
• Journal: Folia Biologica
• Year: 1995
• Volume: 43
• Issue: 3-4
• Pages: 111-114

Contributors

author

L. Mazur

• Document Type: article
• Publication order reference: L.Mazur