The role of domestic pig in somatic cell cloning and transgenesis

• Authors: M. Skrzyszowska , M. Samiec
• Languages of publication: PL

Abstracts

EN

A stimulus for development of the studies on pig somatic cell cloning, especially in recent years, was above all the possibility of its practical application for production of transgenic piglets using in vitro transfected nuclear donor cells and multiplication of genetically-engineered sows and boars generated so far, on the grounds of important implications for biomedicine, pharmacy and agriculture. However, effective pig somatic cell nuclear transfer, avoiding the sexual reproduction pathway, creates a possibility of providing numerous monogenetic and monosexual offspring derived not only from genetically-transformed individuals, but also from adult (postpubertal) animals of high genetic merit. Generation of cloned transgenic pigs for biomedical purposes to obtain recombinant xenogeneic proteins or organs suitable in xenotransplantology, or to create cell (gene) therapy foundations for a number of serious monogenic diseases that induce heritable (congenital) developmental anomalies, is perceived as a service to humanity.

Keywords

EN

CLONING; PIG; SOMATIC CELL; TRANSGENESIS; XENOTRANSPLANTATION

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2006
• Issue: 1
• Pages: 53-67

Contributors

author

M. Skrzyszowska

author

M. Samiec

• Document Type: REVIEW
• Publication order reference: Marcin Samiec, Dzial Biotechnologii Rozrodu Zwierzat, Instytut Zootechniki, 32-083 Balice k. Krakowa, Poland