EN
Oxidative DNA damage produced by free radicals has been implicated to play a role in mutagenesis, carcinogenesis and aging.There is, therefore, increasing interest in teh development of accurate assays for measuring DNA base damage.Such assays should help to define the biological consequences of oxidative DNA modifications and to identify enzymatic repair pathways.The present article describes the potential usefulness of different technique for chemical characterizatoin and quantitation of ixidative modifications in DNA.