Biosythesis of gonadotropins in vivo

• Authors: K. Kochman , A. Gajewska
• Languages of publication: EN

Abstracts

EN

GnRh is potent stimulator of gonadotropin's alpha and beta chains synthesis in vivo.Stimulation of LH-beta gene transcription requires pulsatile GnRH administration but the transcription of alpha subunit can be stimulated independently of GnRH mode of administration.Castration increases whereas in vivo estradiol and testostrone replacement decreases the rate of gene transcription of pituitary gonadotropin subunits.Thyroid hormones can enhance or diminsh the pituitery levels of LH-beta and FSH-beta subunit mRNAs in female rats.Inhibin activin and follistatin were shown to be potent regulators of FSH-beta gene expression.

Keywords

EN

FOLLICLE-STIMULATING HORMONE; GENE EXPRESSION REGULATION; GONADOTROPIN; LUTEINIZING HORMONE; PITUITARY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 3
• Pages: 753-756

Contributors

author

K. Kochman

author

A. Gajewska

• Document Type: review
• Publication order reference: K.Kochman