Immunomodulatory effects of selected chemotherapeutics

• Authors: J. Golab , R. Zagozdzon
• Languages of publication: PL

Abstracts

EN

Chemotherapeutics are still regarded as a mainstay of antitumor strategies. A number of observations indicate that these agents might be used at low doses with the same or even better efficacy than the high-dose chemotherapy. The efficacy of the low-dose chemotherapy might be at least partly explained by the regulation of the antitumor immune response. These immunomodulatory effects might be further potentiated by combinations with selected biological response modifiers, such as recombinant cytokines (IL-2, TNF, IL-12). The effectiveness of such combinations has already proved encouraging in pre-clinical models.

Keywords

EN

CHEMOTHERAPY; CYTOKINE; IMMUNOMODULATION; INTERLEUKIN; TUMOR

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2001
• Issue: 3
• Pages: 78-85

Contributors

author

J. Golab

author

R. Zagozdzon

• Document Type: ARTICLE
• Publication order reference: J. Golab, Zak?ad Immunologii, Centrum Biostruktury, Akademia Medyczna, ul. Cha?ubi?skiego 5, 02-004 Warszawa, Poland, e-mail: [e-mail]