Immunotherapy in the management of sepsis

• Authors: J.P. Sikora
• Languages of publication: EN

Abstracts

EN

The work presents the role of Gram-negative bacteria endotoxins, pro- and anti-inflammatory cytokines and reactive oxygen species (ROS) in the complex and not fully explained pathogenesis of sepsis. The so called ?respiratory burst? of neutrophils and antioxidant mechanisms of the host are also discussed. The work has focused on possible approaches to the management of sepsis connected with immunotherapy. Neutralisation of endotoxin lypopolysaccharide (LPS), anti-TNF-alpha therapy with monoclonal antibodies or pentoxifylline (PTXF) as well as soluble recombinant cytokine agonists and antagonists used in clinical trials were taken into consideration. Besides, cytokine manipulation therapy, anti-adhesion techniques or glicocorticoides and antioxidant barrier interference were also described. So far there has been no immunotherapy of sepsis in children of proven clinical efficacy, which prompts aggressive examination of the immune system, aimed at affecting its function.

Keywords

EN

CYTOKINE; IMMUNOTHERAPY; MONOCLONAL ANTIBODY; REACTIVE OXYGEN SPECIES; SEPSIS

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 5
• Pages: 317-324

Contributors

author

J.P. Sikora

• Document Type: REVIEW
• Publication order reference: J. P. Sikora, Department of Pediatric Propedeutics, Institute of Pediatrics, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland