The role of mono-amine oxidase isozymes on reserpineinduced adrenal hormone release in the pigeon (Columba livia)

• Authors: E. Chakrabarti , S. Sengupta , S. Dasadhikari , A. Ghosh
• Languages of publication: EN

Abstracts

EN

The present investigation was performed to study the participation of the specific isozyme of mono-amineoxidase (MAO) during reserpine-modulated release of medullary catecholamines (CAM). This was carried out by pretreatments of pargyline and clorgyline followed by reserpine administration. The findings revealed that the pigeon adrenal contained predominantly MAO-A. Blockade of type B activity by pargyline caused a significant rise in adrenomedullary CAM content in reserpinized pigeons. However, clorgyline (an MAO-A inhibitor) administration followed by reserpine treatment showed no appreciable change in the medullary CAM level, suggesting that type B activity is mainly responsible for reserpine action on the adrenal medulla in the pigeon. In addition, reserpine was also able to decrease the glandular corticosterone content, while pargyline and clorgyline failed to alter this trend in reserpinized pigeons.

Keywords

EN

ADRENAL HORMONE; CATECHOLAMINE; CORTICOSTERONE; MONOAMINE OXIDASE ISOZYME; PIGEON

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
• Journal: Folia Biologica
• Year: 1997
• Volume: 45
• Pages: 113-116

Contributors

author

E. Chakrabarti

author

S. Sengupta

author

S. Dasadhikari

author

A. Ghosh

• Document Type: article
• Publication order reference: E.Chakrabarti, Histophysiology Laboratory, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700019, India