Plasma homocysteine level and the course of ischemic stroke

• Authors: J. Pniewski , M. Chodakowska-Zebrowska , R. Wozniak , K. Stepien , A. Stafiej
• Languages of publication: EN

Abstracts

EN

Increased level of homocysteine (Hcy) in blood seems to influence negatively the course of ischemic stroke (IS), the possible mechanism of this action could be acceleration of oxidative stress. The aim of this study is to assess the influence of Hcy level in patients with IS on the prognosis 3 moths after the stroke onset. 75 patients aged 68.27 12.62 years, with the diagnosis of first ever IS were examined. Patients with the symptoms corresponding with TACS at the beginning of stroke and with diminished level of consciousness were not included. The level of Hcy over 15 mol/l was assessed as mild hiperhomocysteinemia (MHcy). 74 (98.7%) patients were assessed 3 months after IS onset in the Rankin scale. Recovery was assessed, according to Rankin Scale: good recovery (GR) 0-2, bad recovery (BR) 3-5 and death. MHcy was seen in 9 (14.5%) with GR and in 8 (66.7%) with BR (P=0,0005). MHcy increases the risk of BR 11.78 times (95%CI 2.93-47.42).

Keywords

EN

HOMOCYSTEINE; ISCHEMIC STROKE; PROGNOSIS

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2003
• Volume: 63
• Issue: 2
• Pages: 127-130

Contributors

author

J. Pniewski

author

M. Chodakowska-Zebrowska

author

R. Wozniak

author

K. Stepien

author

A. Stafiej

• Document Type: ARTICLE
• Publication order reference: J. Pniewski, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland