Superior laryngeal nerve section abolishes capsaicin evoked chemoreflex in anaesthetized rats

• Authors: K. Kaczynska , M. Szereda-Przestaszewska
• Languages of publication: EN

Abstracts

EN

Respiratory effects of an intravenous injection of capsaicin were investigated in nine vagotomized and subsequently laryngeally deafferentated, urethane- and chloralose- anaesthetized and spontaneously breathing rats. Bolus injection of capsaicin (5 g/kg) into the right femoral vein induced an expiratory apnoea of 4.23 0.63 s duration (mean SEM). In post-apnoeic breathing, tidal volume increased by 14% from the control level (P<0.05) in all nine rats treated by vagotomy. Section of the superior laryngeal nerves (SLNs) precluded the occurrence of apnoea. Results of this study indicate that in vagotomized rats sensory input from the larynx constitutes an important pathway to the nodose ganglia endowed with capsaicin receptors.

Keywords

EN

APNOEA; BREATHING; CAPSAICIN; RAT

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2002
• Volume: 62
• Issue: 1
• Pages: 19-24

Contributors

author

K. Kaczynska

author

M. Szereda-Przestaszewska

• Document Type: ARTICLE
• Publication order reference: K. Kaczynska, Laboratory of Respiration Physiology, Department of Neurophysiology, Medical Research Centre Polish Academy of Sciences, 5 Pawinskiego St.,02-106 Warsaw, Poland