Local tissue complement synthesis ? fine tuning a blunt instrument

• Authors: J.E. Marsh , W. Zhou , S.H. Sacks
• Languages of publication: EN

Abstracts

EN

Complement is important to host defense and the regulation of inflammation. The liver is overwhelmingly the major source of circulating complement. However, many other organs are capable of synthesizing some or all of the complement components in a regulated tissue-specific manner. There is increasing evidence that this locally generated complement is biologically active and exerts powerful effects within the local environment. We review the role of local complement synthesis within different organs and speculate on its implication for immune and metabolic functions.

Keywords

EN

ADIPOCYTE; BONE MARROW; BRAIN; GLOMERULONEPHRITIS; KIDNEY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 1 suppl.
• Pages: 41-46

Contributors

author

J.E. Marsh

author

W. Zhou

author

S.H. Sacks

• Document Type: REVIEW
• Publication order reference: J.E. Marsh, Department of Nephrology and Transplantation, Floor 5, Thomas Guy House, Guy?s Hospital, King?s College, London, SE1 9RT, UK