The role of genetic factors apoptosisi and 14-3-3 protein in the induction of some atopic diseases

• Authors: E. Jagiello , M. Krasnowska , M. Gacko , M. Rucinska , Z. Skrzydlewski
• Languages of publication: PL

Abstracts

EN

In this review we try to summarize some of the new informations about the genetic base of bronchial asthma. We also mention apoptosis (programmed cell death) as the process modulating cell proliferation, differentiation and death. According to the latest reports, the disorders of the regulation of apoptosis may play an important role an the pathogenesis of autoimmunologic and atopic diseases (including bronchial asthma), AIDS and neoplasmatic diseases. There is a linkage between the induction of apoptosis and signal transduction disorders. We describe the Raf/MECK/ERK/MAP signal transduction pathway and 14-3-3 protein - the peptide which possibly might participate in the initiation of the programmed cell death.

Keywords

EN

APOPTOSIS; ATOPIC DISEASE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1997
• Volume: 51
• Issue: 4
• Pages: 385-398

Contributors

author

E. Jagiello

author

M. Krasnowska

author

M. Gacko

author

M. Rucinska

author

Z. Skrzydlewski

• Document Type: article
• Publication order reference: E.Jagiello, Klinika Chorob Wewnetrznych i Alergologii AM, ul.Traugutta 57, 50-417 Wroclaw, Poland