The modulatory effect of aminothiols on the clastogenic activity of X-rays assayed by the in vivo mouse micronucleus test

• Authors: L. Mazur
• Languages of publication: EN

Abstracts

EN

The modulatory effect of AET (S-2-aminoethylisothio-uronium bromide hydrobromide) and WR-2721 (S-2-/3-ami- nopropylamino/ethylphosphorothioic acid) on the clastogenic activity of X-rays was assessed by the in vivo mouse micronucleus test. The frequency of micronucleated polychromatic erythrocytes (MNPCEs) in the peripheral blood of adult male Swiss mice exposed to 5 Gy X-rays alone, or treated with AET or WR-2721, at a dose of 200 mg/kg body weight, 15 or 30 minutes prior to X-irradiation, respectively, was determined during a fifteen-day period. The number of micronuclei increased on day 1 post-irradiation in X-irradiated mice and declined thereafter with the frequency of MNPCEs remaining lower in the thiol pre-treated mice. A more effective protection against the clastogenic activity of X-rays in the erythropoietic system was observed after WR-2721 administration than AET application.

Keywords

EN

MICRONUCLEUS TEST; MOUSE PERIPHERAL BLOOD; X-RAY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Institute of Systematics and Evolution of Animals, Polish Academy of Sciences
• Journal: Folia Biologica
• Year: 1996
• Volume: 44
• Pages: 55-59

Contributors

author

L. Mazur

• Document Type: article
• Publication order reference: L.Mazur, Laboratory of Experimental Haematology and Toxicology, Department of Animal Physiology, Institute of Zoology, Jagiellonian University, R. Ingardena 6, 30-060 Krakow, Poland.