Influence of diethylenetriamine (DETA) and sodium nitroprusside (NaNP) on sister chromatid exchange frequency and cell kinetics in cultured human lymphocytes

• Authors: M. Perkowska , M. Szczygiel , A. Wozniak , J. Limon
• Languages of publication: EN

Abstracts

EN

Diethylenetriamine (DETA) and Sodium Nitroprusside (NaNP), the exogenous NO-generating compounds, were tested for their genotoxicity in human lymphocytes in vitro using the sister chromatid exchange (SCE) technique. Both compounds were found to be inactive in inducing SCE in concentrations from 0.3 to 30 pM. However both compounds displayed an inhibiting effect on cell kinetics.

Keywords

EN

CELL CYCLE KINETICS; DIETHYLENETRIAMINE; MYOCARDIAL ISCHEMIA; RESTENOSIS; SISTER CHROMATID; SODIUM NITROPRUSSIDE

Discipline

• GENETICS: GENETICS

• Publisher: Institute of Plant Genetics, Polish Academy of Sciences
• Journal: Journal of Applied Genetics
• Year: 2001
• Volume: 42
• Issue: 2
• Pages: 233-235

Contributors

author

M. Perkowska

author

M. Szczygiel

author

A. Wozniak

author

J. Limon

• Document Type: SHORT COMMUNICA
• Publication order reference: M. Perkowska, Department of Biology and Genetics, Medical University of Gdansk, ul. Debinki 1, 80-211 Gdansk, Poland.