The NFB/IB system in acute inflammation

• Authors: A.B. Lentsch , P.A. Ward
• Languages of publication: EN

Abstracts

EN

The transcription factor NFkappaB is a primary regulator of a wide variety of proinflammatory mediators. Under normal conditions, NFkappaB is retained in the cytoplasm bound to inhibitory proteins of the I kappaB family. Following cell activation, a number of signal transduction pathways lead to degradation of I kappaB proteins which results in nuclear translocation of NFkappaB and the ensuing transcriptional activation of proinflammatory genes. Several endogenous regulatory mediators, which function to prevent uncontrolled inflammation, exert their effects by blocking the activation of NFkappaB. Thus, NFkappaB appears to be at the heart of the acute inflammatory response. The present review discusses the role of NFkappaB in the induction and propagation of the acute inflammatory response as well as the regulation and resolution of this process.

Keywords

EN

ACUTE INFLAMMATION; ACUTE INFLAMMATORY; INHIBITORY PROTEIN; RESPONSE; TRANSCRIPTION FACTOR

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 2
• Pages: 59-63

Contributors

author

A.B. Lentsch

author

P.A. Ward

• Document Type: REVIEW
• Publication order reference: A.B. Lentsch, Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA,