Differential effects of CD40 stimulation on normal and neoplastic cell growth

• Authors: J.L. Ziebold , J. Hixon , A. Boyd , W.J. Murphy
• Languages of publication: EN

Abstracts

EN

CD40 is a molecule in the tumor necrosis factor receptor/nerve growth factor receptor (TNFR/NGFR) family that is present on both normal and neoplastic B lineage cells. It is also expressed on carcinoma and melanoma cells and can be augmented with interferon gamma CD40 stimulation in normal Bcells has been demonstrated to promote normal B cell differentiation and growth in vitro. In contrast to these effects, CD40 stimulation by either anti-CD40 antibodies or a recombinant soluble CD40 ligand can inhibit the growth of human breast carcinomas and aggressive histology B lymphomas in vitro and in vivo. This is believed to occur by activation- -induced cell death (AICD) in which stimuli that promote the growth of normal cell types inhibit the growth of neoplastic counterparts. This occurs through the induction of apoptosis, necrosis and/or cell cycle arrest. Thus, CD40 stimulation may be of potential clinical use in the treatment of carcinomas and B cell lymphomas. This review shall provide an overview of the various effects of CD40 stimulation on both normal and neoplastic cell types.

Keywords

EN

APOPTOSIS; INTERFERON GAMMA; LYMPHOMA

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 4
• Pages: 225-233

Contributors

author

J.L. Ziebold

author

J. Hixon

author

A. Boyd

author

W.J. Murphy

• Document Type: REVIEW
• Publication order reference: J.L. Ziebold, NCI-FCRDC, Laboratory of Leukocyte Biology, Frederick, Maryland, USA