Antibodies and drug-carriers in targeted therapy - progress and limitations

• Authors: L. Konieczny , Piekarska B. Piekarska , B. Piekarska , Roterman I. Roterman , I. Roterman , Rybarska J. Rybarska , J. Rybarska , Stopa B. Stopa , B. Stopa , Zemanek G. Zemanek , G. Zemanek
• Languages of publication: PL

Abstracts

EN

The paper addresses the problems of carriers and antibodies in targeted therapy. Also the new material of liquid crystalline nature, designed for use as a drug vehicle in the immune targeting technique is presented and its property is discussed. Obtained by self-assembling, the ribbon-like supramolecular organisation products of some azo-dyes, particularly including Congo red and Evans blue, form micellar bodies of this carrier. They bind spontaneously and selectively to immune complexes but not to free antibodies. The binding strongly enhances the antigen - antibody interaction. Micelles of the carrier composed of self-assembled molecules easily incorporate many foreign substances including drugs, favouring however those of possibly planar molecules. The excess of carrier leaves the organism rapidly through the urine tract, reducing the possible side effects. The nature of chromonic liquid crystalline material is suitable for many modifications and adapting elaboration.

Keywords

EN

ANTIBODY; CARRIER; DRUG; IMMUNOTARGETING

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2001
• Issue: 3
• Pages: 37-52

Contributors

author

L. Konieczny

author

Piekarska B. Piekarska

author

B. Piekarska

author

Roterman I. Roterman

author

I. Roterman

author

Rybarska J. Rybarska

author

J. Rybarska

author

Stopa B. Stopa

author

B. Stopa

author

Zemanek G. Zemanek

author

G. Zemanek

• Document Type: ARTICLE
• Publication order reference: L. Konieczny, Instytut Biochemii Lekarskiej, Collegium Medicum, Uniwersytet Jagiellonski, ul. Kopernika 7, 31-034 Krakow, Poland