Anti-HIV activities and mechanisms of antisense oligonucleotides

• Authors: T. Hatta , T. Inagawa , T. Kuwasaki , Y. Kinzuka , K. Takai , S. Yokoyama , H. Nakashima , N. Yamamoto , H. Takaku
• Languages of publication: EN

Abstracts

EN

We demonstrated that unmodified and modified (phosphorothioate) oligonucleotides prevent cDNA synthesis by the AMV, MMLV, and HIV reverse transcriptases.WE also describe tha long-term treatment of human immunodeficiency virus-infected cells with antisense phosphorothioate oligonucleotides.

Keywords

EN

ANTISENSE OLIGONUCLEOTIDE; HIV; PHOSPHOROTHIOATE; REVERSE TRANSCRIPTASE

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 1996
• Issue: 4
• Pages: 116-131

Contributors

author

T. Hatta

author

T. Inagawa

author

T. Kuwasaki

author

Y. Kinzuka

author

K. Takai

author

S. Yokoyama

author

H. Nakashima

author

N. Yamamoto

author

H. Takaku

• Document Type: article
• Publication order reference: Hiroshi Takaku, Department of INdustrial Chemistry, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275, Japan