Peptide loading of nascent MHC class i molecules

• Authors: S. Vukmanovic , M. Lilic , F.R. Santori , S. Demaria , K. Kulig
• Languages of publication: EN

Abstracts

EN

A critical molecular interaction during assembly of the major histocompatibility complex (MHC) class I molecules takes place between the heavy chain and the transporter-associated with antigen-processing (TAP) complex. The recent mapping of regions of the heavy chain involved in the binding to TAP suggests a complex molecular interaction essential for the cell surface expression of the MHC class I. The advances made in understanding the TAP-MHC class I interaction are reviewed and discussed here.

Keywords

EN

ANTIGEN PROCESSING; CD8+ CELL; CYTOTOXICITY; T LYMPHOCYTE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 3
• Pages: 195-201

Contributors

author

S. Vukmanovic

author

M. Lilic

author

F.R. Santori

author

S. Demaria

author

K. Kulig

• Document Type: REVIEW
• Publication order reference: S. Vukmanovic, Michael Heidelberger Division of Immunology, Department of Pathology, and Kaplan Coprehensive Cancer Center, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA