Regulation of T cell homeostasis by JAKs and STATs

• Authors: J.A. Ross , Z.S. Nagy , H. Cheng , S.M. Stepkowski , R.A. Kirken
• Languages of publication: EN

Abstracts

EN

Regulation of T cell homeostasis is critical for maintaining normal immune function. An imbalance in T cell proliferation can result in disorders ranging from cancer and autoimmunity to immunodeficiencies. Full activation of T cells requires three sequential signals, where signal 3, which is delivered by multiple cytokines, regulates proliferation, differentiation, and survival/death. Signaling from cytokines through their receptors is primarily delivered by two molecular families, namely Janus tyrosine kinases (JAKs) and signal transducers and activators of transcription (STATs). Invaluable knowledge about JAKs and STATs has arisen from studies of mice made genetically deficient in these molecules, analyses of tumor models, and studies of expression patterns by proteomics/genomics, which all have begun to define the role of JAKs and STATs in survival versus apoptosis. These findings also have suggested ways in which JAKs and STATs may be manipulated for therapeutic intervention in lymphoid-derived diseases. This review seeks to focus on the role of JAK tyrosine kinases and STAT transcription factors in mediating the lymphocyte life cycle and how they might be manipulated for therapeutic applications.

Keywords

EN

APOPTOSIS; CYTOKINE; HOMEOSTASIS; T CELL; TRANSCRIPTION; TYROSINE KINASE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2007
• Volume: 55
• Issue: 4
• Pages: 231-245

Contributors

author

J.A. Ross

author

Z.S. Nagy

author

H. Cheng

author

S.M. Stepkowski

author

R.A. Kirken

• Document Type: REVIEW
• Publication order reference: Robert A. Kirken, University of Texas at El Paso, Department of Biological Sciences, 500 W. University Ave., El Paso, TX 79902, USA