Tau phosphorylation and assembly

• Authors: A. Gomez-Ramos , M.A. Smith , G. Perry , J. Avila
• Languages of publication: EN

Abstracts

EN

Neurofibrillary tangles, one of the aberrant structures found in the brain of Alzheimer's disease patients are mainly composed of tau in hyperphosphorylated form.Thus, a possible relation between phosphorylation and assembly of tau proteins has been analysed. By doing in vitro studies we have observed that in certain conditions, where compounds from oxidative stress are present, the capacity of tau for self assembly increases upon phosphorylation.

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2004
• Volume: 64
• Issue: 1
• Pages: 33-39

Contributors

author

A. Gomez-Ramos

author

M.A. Smith

author

G. Perry

author

J. Avila

• Document Type: REVIEW
• Publication order reference: J. Avila, Centro de Biologia Molecular, (CSIC/UAM), Facultad de Ciencias, Universidad Autionoma de Madrid, Cantoblanco, 28049 Madrid, Spain