Modeling the meta-dynamics of lymphocyte repertoires

• Authors: R. Mahr
• Languages of publication: EN

Abstracts

EN

The complexity of biological systems, and the explosion of the quantity of biological information which is rapidly becoming available from experimental and clinical studies, necessitate the use of theoretical tools, namely, mathematical and computational modeling. The vertebrate adaptive immune system, with its learning and memory capabilities, is a particularly rich source of modeling challenges. Most difficult within this area is the study of lymphocyte repertoires ? the generation of their diversity and the forces that shape the ever-changing dynamics of lymphocyte clones. I review several examples of problems in lymphocyte repertoire modeling, demonstrate the types of solutions employed, and highlight the contribution of these theoretical studies to immunological research.

Keywords

EN

COMPUTER SIMULATION; LYMPHOCYTE DEVELOPMENT; LYMPHOCYTE REPERTOIRE; MATHEMATICAL MODEL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 2
• Pages: 111-120

Contributors

author

R. Mahr

• Document Type: REVIEW
• Publication order reference: R. Mahr, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel