Mechanisms of Mycobacterium avium pathogenesis

• Authors: L.E. Bermudez , D. Wagner , D. Sosnowska
• Languages of publication: EN

Abstracts

EN

Infections caused by M. avium are common in AIDS patients and patients with chronic lung diseases. The bacterium can be acquired both by the intestinal route and respiratory route. M. avium is capable of invading mucosal epithelial cells and translocate across the mucosa. The bacterium can infect macrophages interfering with several functions of the host cell. The host defense against M. avium is primarily dependent on CD4+ T lymphocytes and NK cells. Activated macrophages can inhibit or kill intracellular bacteria by mechanisms that are currently unknown but M. avium can invade resting macrophages and suppress key aspects of its function by triggering the release of TGF-beta and IL-10. Co-infection with HIV-1 appears to be mutually beneficial with both organisms growing faster.

Keywords

EN

MYCOBACTERIUM AVIUM; PATHOGENESIS

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 5
• Pages: 521-528

Contributors

author

L.E. Bermudez

author

D. Wagner

author

D. Sosnowska

• Document Type: REVIEW
• Publication order reference: L.E. Bermudez, Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, CA 94115, USA