Effects of cervical sympathetic nerve stimulation on the cerebral microcirculation: possible clinical implications

• Authors: M. Passotore , F. Deriu , S. Roatta , C. Grassi , G. Micieli
• Languages of publication: EN

Abstracts

EN

The action of bilateral cervical sympathetic nerve (CNS) stimulation on mean cerebral blood flow (CBF) and on its rhythmical fluctuations was studied in normotensive rabbits by using laser-Doppler flowmetry (LDF). A reduction in mean CBF, mediated by alfa-adrenoceptors, was the predominant effect; it was more often present and larger in size in the vascular beds supplied by the carotid than in those supplied by the vertebro-basilar system. This suggests that the sympathetic action facilitates a redisrtibution of blood flow to the brain stem. The effect induced by CSN stimulation on CBF spontaneous oscillations was a consistent decrease in amplitude and an increase in frequency, irrespective of the changes produced on the mean level of CBF. The possible implications of the sympathetic actions on the state of the blood-brain barrier (BBB) are discussed. Experimental and clinical data dealing with the infuence of sympathetic activation on the cerebrovascular system have been compared. As a result the possibility of analysing the spontaneous oscillations of CBF for clinical purposes is suggested.

Keywords

EN

BLOOD-BRAIN BARRIER; CEREBROVASCULAR CIRCULATION; LASER-DOPPLER FLOWMETRY; MICROCIRCULATION; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; VASOMOTION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 1
• Pages: 117-127

Contributors

author

M. Passotore

author

F. Deriu

author

S. Roatta

author

C. Grassi

author

G. Micieli

• Document Type: proceeding
• Publication order reference: M.Passotore