Polyamines and their role in tumour growth

• Authors: J. Godlewska , W. Peczynska-Czoch
• Languages of publication: PL

Abstracts

EN

The polyamines - putrescine, spermidine and spermine - are normal constituents of prokariotic and eukariotic cells. These small polycationic, aliphatic compounds are essential for normal cell proliferation. Cells cease to proliferate, when they are depleted of their polyamines, but resume a normal growth rate after supplementation with these compounds. Because of the sustained increase in polyamine biosynthesis in preneoplastic and neoplastic tissues, a great deal of interest has been given to the polyamine biosynthesis, network and uptake systems as a target in antineoplastic strategies.

Keywords

EN

POLYAMINE; TUMOUR GROWTH

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 6
• Pages: 757-777

Contributors

author

J. Godlewska

author

W. Peczynska-Czoch

• Document Type: ARTICLE
• Publication order reference: J. Godlewski, Instytut Chemii Organicznej, Biochemii i Biotechnologii, Politechnika Wroclawska, Wybrzeze Wyspianskiego 29, 50-370 Wroclaw, Poland