Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

• Authors: F. Ensoli , V. Fiorelli , Cristofaro M. De- , Muratori D. Santini , A. Novi , A. Isgro , F. Aiuti
• Languages of publication: EN

Abstracts

EN

Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.

Keywords

EN

AIDS; NEURAL CELL; NEUROLOGICAL DISORDER

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 4
• Pages: 259-266

Contributors

author

F. Ensoli

author

V. Fiorelli

author

Cristofaro M. De-

author

Muratori D. Santini

author

A. Novi

author

A. Isgro

author

F. Aiuti

• Document Type: REVIEW
• Publication order reference: F. Ensoli, Department of Allergy and Clinical Immunology, University of Rome, La Sapienza, 00185 Rome, Italy