Immunopathology of Grave's disease

• Authors: Z. Baj , T. Ferenc , A. Lewinski
• Languages of publication: PL

Abstracts

EN

The pathogenesis Graves' disease, an autoimmune disorder, is not fully understood. Immune disturbances, genetic predisposition and environmental factors, affecting thyroid gland, appear to play the main role in contribution and development of the disease. Autoreactive T lymphocyte infiltrates in the thyroid gland and/or in the retroorbital tissues and autoantibodies to TSH receptor detected in almost all of the patients, have been considered to be responsible for hyperthyroidism, ophtalmopathy, pretibial dermopathy and goiter. In this review, we describe some recent reports on the pathophysiological and immunological aspects of the thyroidal and extrathyroidal manifestations of the Graves' disease.

Keywords

EN

GRAVES' DISEASE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1997
• Volume: 51
• Issue: 5
• Pages: 531-546

Contributors

author

Z. Baj

author

T. Ferenc

author

A. Lewinski

• Document Type: article
• Publication order reference: Z. Baj, Zaklad Tyreologii Instytutu Endokrynologii AM, ul. Sterlinga 5, 91-425 Lodz, Poland