Non-opioid peptides for analgesia

• Authors: J. Chrubasik , S. Chrubasik , E. Martin
• Languages of publication: EN

Abstracts

EN

Amongst the <spinal peptide> candidates believed to be involved in the mediation of analgesia, only somatostatin fulfills the criterium of a real analgesia substance. Spinal somatostatin specifically blocks the transmission of painful stimuli. Spinal calcitonin may lower the opioid dose requirement in patients with bone metastases but it fails to relieve acute pain. The usefulness of ACTH and CRF for treatment of pain remains to be established. The role of CCK-8, vasopressin and <neurotensin> is unclear. The contradictory findings on antinociception using simple rodent withdrawl reflex tests (e.g. the tail test), or more complex behavioral tests in which supraspinal sensory processing is involved, (e.g. the hot plate test), indicate that these tests are inappropriate when neuropeptides are employed. Furthermore, due to their inability to predict analgesia in humans, they do not fulfill the guidelines proposed by the IASP that animal test procedured have to be for the benefit of humans.

Keywords

EN

ACTH; CALCITONIN; NEUROTENSIN; SOMATOSTATIN; SPINAL ANALGESIA; VASOPRESSIN

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1993
• Volume: 53
• Issue: 1
• Pages: 289-296

Contributors

author

J. Chrubasik

author

S. Chrubasik

author

E. Martin

• Document Type: paper