Rat cerebral mitochondrial glutaminase activity is unaffected by moderate hyperammonemia in two models

• Authors: J. Albrecht , W. Hilgier , L. Faff
• Languages of publication: EN

Abstracts

EN

The phosphate-dependent (PAG) and phosphate-independent (PIndG) glutaminase activities were measured in cerebral perikaryal mitochondria derived from rats subjected to ammonium acetate- induced "simple" hyperammonemia (SHA) or thioacetamide-induced hepatic encephalopathy (HE).These two moderately hyperammonemic conditions were previously found to be accoopanied by pronounced changes in virtually all the enzyme activities coupling the tricarboxilic acid cycle to the synthesis and metabolism of the excitatory neurotransmitter glutamate.Both PAG and PIndG remained unaffected by SHA or HE, indicating that htey do not contribute to the cerebral glutamine/glutamate imbalance associated with both conditions.

Keywords

EN

HEPATIC ENCEPHALOPATHY; HYPERAMMONEMIA; MITOCHONDRIA

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 2
• Pages: 545-548

Contributors

author

J. Albrecht

author

W. Hilgier

author

L. Faff

• Document Type: article
• Publication order reference: J.Albrecht