Trafficking of FoxP3+ regulatory T cells: myths and facts

• Authors: C.H. Kim
• Languages of publication: EN

Abstracts

EN

Fork head box P3 (FoxP3+) regulatory T cells (Tregs) are specialized T cells for the prevention of hyperimmune responses and autoimmunity. Tumors and pathogens can hijack FoxP3+ Tregs to evade host immune responses. There is an increasing body of evidence that trafficking of FoxP3+ Tregs is important for their effective suppression of target cells. Because of their distinctive functions and gene expression phenotype, the migratory behavior of FoxP3+ Tregs has been somewhat mystified. The myths are that they have unique trafficking receptors and migratory behaviors that are different from those of conventional T cells. Another related myth is that FoxP3+ regulatory T cell subsets have a fixed trafficking behavior from the time they are generated in the thymus. Recent progress in trafficking receptors and the migratory behavior of FoxP3+ Tregs are reviewed here and the validity of these myths examined.

Keywords

EN

CHEMOKINE RECEPTOR; FORK HEAD BOX P3; INTEGRIN; MIGRATION; SELECTIN; T CELL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2007
• Volume: 55
• Issue: 3
• Pages: 151-159

Contributors

author

C.H. Kim

• Document Type: REVIEW
• Publication order reference: Chang H. Kim, Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA