Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy

• Authors: Halina Kroh , Anna Taraszewska , Edmund Ruzikowski , Jerzy Bidzinski , Miroslaw J. Mossakowski
• Languages of publication: EN

Abstracts

EN

The study was performed on cerebral tissue resected during temporal lobectomy in 16 patients whose long-standing cryptogenic epilepsy did not submit to anticonvulsive drugs. Cases presenting definite etiological factors such as CNS trauma, infection or neoplasm were excluded. Neuropathological investigations disclosed microangiomas and focal vascular malformations in the meninges and tissue in 7 patients. Neuronal heterotopias in the white matter and of the white matter in the cortex were observed in 3 cases, Main cortical changes were: neuronal loss,chronic neuronal degeneration, perineuronal satellitosis, and GFAP-positive submeningeal gliosis, especially at the bottom of sulci, perivascular gliosis and laminar or diffuse gliosis. the changes in the hippocamus were most enhanced in the end-plate and in the sector H3 of the pyramidal layer. Astrocytic gliosis in the white matter presented distinct GFAP and S-100 immunostaining; the latter involved in some cases a wider area than the GFAP reaction. The above named changes are analysed with regard to the presumed epileptogenic factors and to the postepileptic damage.

Keywords

EN

EPILEPSY; GLIOSIS; NEURON; TEMPORAL LOBECTOMY

Discipline

• NEUROSCIENCE: NEUROSCIENCE

• Publisher: Association of Polish Neuropathologists; Medical Research Centre, Polish Academy of Sciences
• Journal: Neuropatologia Polska
• Year: 1992
• Volume: 30
• Issue: 2
• Pages: 133-146

Contributors

author

Halina Kroh

author

Anna Taraszewska

author

Edmund Ruzikowski

author

Jerzy Bidzinski

author

Miroslaw J. Mossakowski

• Document Type: article
• Publication order reference: Halina Kroh