Langerhans cells in vulvar lichen sclerosus and vulvar squamous cell carcinoma

• Authors: H. Rotsztejn , E. Trznadel-Budzko , D. Jesionek-Kupnicka
• Languages of publication: EN

Abstracts

EN

Introduction: Langerhans cells (LCs), specializing in antigen presentation, are a very important part of the skin immune system (SIS). Materials and Methods: Skin biopsies from 22 women with vulvar lichen sclerosus (LS): 15 patients with early and 7 with the late stage of the disease, were evaluated. Five women with vulvar squamous cell carcinoma (SCC) were also examined. The control group consisted of 9 women who underwent plastic surgery of the vulvar region. Immunohistochemical staining was performed on formalin-fixed paraffin-embedded tissues samples using antihuman CD1a antibody (NCL-CD1a-235, Novocastra). Results: Increased numbers of LC stainings were present in early LS, whereas decreased numbers of these cells were present in late LS and in SCC compared with the control group. Conclusions: This study showed that dysregulation of the SIS may lead to suppression of LCs in the vulvar epithelium and may be one of the reasons for a higher tendency for carcinogenesis in the vulvar region.

Keywords

EN

CELL CARCINOMA; LANGERHANS CELL; LICHEN SCLEROSUS; VULVA

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2006
• Volume: 54
• Issue: 5
• Pages: 363-366

Contributors

author

H. Rotsztejn

author

E. Trznadel-Budzko

author

D. Jesionek-Kupnicka

• Document Type: ARTICLE
• Publication order reference: H. Rotsztejn, Dermatology Section of the Polish Mother?s Memorial Hospital, 93-338 Lodz, Rzgowska 281/289, Poland