The vacuolating cytotoxin of Helicobacter pyroli

• Authors: A. Przondo-Mordarska , J. Zakrzewska-Czerwinska
• Languages of publication: PL

Abstracts

EN

Helicobacter pylori is now recognized as the major causative agent of chronic superficial gastritis in humans. The virulence factors of H. pylori are still poorly understood. Vacuolating cytotoxin (VacA) is one of the factors that has been identified so far. VacA induces cytoplasmic vacuolation in eukaryotic cells. The vacA gene encodes a precursor protein of 140 kDa which consists of a 33-amino acid signal sequence, the 87 kDa cytotoxin and a 50 kDa C-terminal domain. The 50 kDa domain is involved in translocation of VacA across outer membrane. Sequence analysis of vacA gene derived from different strains of H. pylori revealed the existence of several families of vacA gene allels. Analysis of a clinically isolated strains of H. pylori showed the correlation between presence of specific vacA allels, VacA activity and peptic ulceration

Keywords

EN

CYTOTOXIN; HELICOBACTER PYLORI

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1996
• Volume: 50
• Issue: 4
• Pages: 309-320

Contributors

author

A. Przondo-Mordarska

author

J. Zakrzewska-Czerwinska

• Document Type: article
• Publication order reference: A. Przondo-Mordarska, al. Piastow 31, 52-424 Wroclaw, Poland