Bioavailability of mesalazine from two coated formulation tablets

• Authors: Tadeusz W. Hermann , Franciszek K. Główka , Jacek Hermann , Maciej Zabel
• Languages of publication: EN

Abstracts

EN

HPLC methodology with a fluorescent detector is suitable for bioavailability studies of investigated generic tablets Mesalazine 250 mg (Jelfa, Poland) versus standard Salofalk tablets (Dr. Falk, Germany). The investigations were completed in ten healthy subjects in a double way crossover design. Only one bioavailability parameter – time for maximum mesalazine plasma concentration (tmax ) and overall elimination rate constants are significantly greater for the above standard tablets. The parameters like maximum plasma drug concentration (Cmax), lag time for absorption (Tlag), biological half-life time (t1/2 ) are also more favorable for the standard, but these values are not significantly different.

Keywords

EN

bioavailability; human subjects; 5-ASA matrix tablets; pharmacokinetic parameters; TopFit computer program; sustained release

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2019
• Volume: 76
• Issue: 1
• Pages: 67-73

Dates

published

2019-02-28

Contributors

author

Tadeusz W. Hermann

author

Franciszek K. Główka

author

Jacek Hermann

author

Maciej Zabel

Identifiers

DOI

10.32383/appdr/92604