Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations

• Authors: Maria Makuszewska , Małgorzata Litwiniuk-Kosmala , Robert Bartoszewicz , Kazimierz Niemczyk

Abstracts

EN

Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene.
Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.

Keywords

EN

gene expression; merlin; microRNA; molecular biology; neuroblastoma

• Publisher: Index Copernicus International
• Journal: Polski Przegląd Otorynolaryngologiczny
• Year: 2020
• Volume: 9(3)
• Pages: 23-29

Dates

published

2020-09-28

Contributors

author

Maria Makuszewska

author

Małgorzata Litwiniuk-Kosmala

author

Robert Bartoszewicz

author

Kazimierz Niemczyk

Identifiers

DOI

10.5604/01.3001.0014.4201