Lipidy w interakcjach z hormonami tarczycy

• Authors: Danuta Rosołowska-Huszcz , Katarzyna Lachowicz , Ewelina Pałkowska

Title variants

EN

Lipid and thyroid hormone interactions

• Languages of publication: PL EN

Abstracts

PL

Relacje między działaniem hormonów tarczycy i związków lipidowych, kwasów tłuszczowych, eikozanoidów i steroli, stanowią ważny element utrzymania homeostazy energetycznej ustroju. Hormony tarczycy wpływają na syntezę i utlenianie kwasów tłuszczowych, syntezę cholesterolu, jego wychwyt i transport odkomórkowy. Tłuszcz diety z kolei, w zależności od ilości i składu, zmienia funkcjonowanie elementów osi podwzgórzowo-przysadkowo-tarczycowej. Jądrowe receptory T3 i czynniki transkrypcyjne wiążące związki o charakterze lipidowym są zaangażowane w regulację ekspresji tych samych genów, wykazują znaczne podobieństwa strukturalne, w tym miejsc wiązania DNA i sekwencji wiążących w DNA. Wszystkie te receptory tworzą heterodimery z receptorami kwasu 9-cis-retinowego, RXR. Występują między nimi zarówno reakcje współdziałania, jak i antagonizmu. Receptor aktywowany przez proliferatory peroksysomalne typu γ wpływa na różnicowanie komórek tarczycy i hamuje procesy zapalne w gruczole.

EN

Relationships between thyroid hormone and lipid compounds: fatty acids, eicosanoid and sterol actions are important for the energy homeostasis. Thyroid hormones affect the fatty acid synthesis and oxidation, cholesterol synthesis and its cellular uptake as well as the reverse transport. In turn, dietary fat in the manner depending on its amount and composition alters the hypothalamus-pituitary-thyroid axis activity. Nuclear thyroid hormone receptors and transcriptional factors binding lipid compounds regulate expression of the same genes, share structural similarities in the DNA binding domains and responsive element. All these receptors form the heterodimers with 9-cis-retinoic acid, RXR. Their interactions include both synergy and antagonism. Proliferator activated receptor type γ stimulates the thyroid cell differentiation and inhibits inflammatory processes in this gland.

Keywords

PL

hormony tarczycy; kwasy tłuszczowe; receptory jądrowe; sterole; tarczyca

• Journal: Kosmos
• Year: 2016
• Volume: 65
• Issue: 3
• Pages: 361-370

Dates

published

2016

Contributors

author

Danuta Rosołowska-Huszcz

• Katedra Dietetyki, Wydział Nauk o Żywieniu Człowieka i Konsumpcji, Szkoła Główna Gospodarstwa Wiejskiego, Nowoursynowska 159c, 02-776 Warszawa, Polska
• Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warszawa, Poland

author

Katarzyna Lachowicz

• Katedra Dietetyki, Wydział Nauk o Żywieniu Człowieka i Konsumpcji, Szkoła Główna Gospodarstwa Wiejskiego, Nowoursynowska 159c, 02-776 Warszawa, Polska
• Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warszawa, Poland

author

Ewelina Pałkowska

• Katedra Dietetyki, Wydział Nauk o Żywieniu Człowieka i Konsumpcji, Szkoła Główna Gospodarstwa Wiejskiego, Nowoursynowska 159c, 02-776 Warszawa, Polska
• Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warszawa, Poland

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